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In addition to the removal of necrotic cell debris, monocyte-derived macrophages can also limit potential neutrophil toxicity by phagocytosis of these cells [105, 112]

7.1.1 Use of cytokine inhibitors Cytokines, particularly pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF- ), interleukin (IL)-1, and IL-6, are known to contribute significantly to BBB dysfunction and neuroinflammation following I/R injury (Jurcau and Simion, 2021)

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